Combinatorial Vaccine against Complement Factor C5a and Amyloid Beta: A New Therapeutic Approach in Alzheimers Disease
نویسندگان
چکیده
منابع مشابه
Combinatorial Vaccine against Complement Factor C5a and Amyloid Beta: A New Therapeutic Approach in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by neuronal loss due to amyloid beta (Aβ) aggregations, neurofibrillary tangles, and prominent neuroinflammation. Inflammatory processes in AD primarily occur in response to misfolded and aggregated proteins, or mislocalized nucleic acids and reactive microglia. Prolonged chronic neuroinflammation is thought to ...
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Spirochetes, biofilms, and innate immune system activity have all been recently found in the brains of Alzheimer’s disease patients. The mechanism and actions of those factors in producing the disease were discussed in those studies. However, neither the production nor the role of beta amyloid was included in the discussion of those studies. In this commentary, we hypothesize how the developmen...
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Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE(-/-) mice. After 24 days, when advanced plaques had developed, C5a or PBS was applied locally at the lesion site in a pluronic gel. Thre...
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ژورنال
عنوان ژورنال: Journal of Clinical & Cellular Immunology
سال: 2017
ISSN: 2155-9899
DOI: 10.4172/2155-9899.1000487